Nephrology · CKD Risk Tool

Kidney Function
& Failure Risk Calculator

Computes eGFR via CKD-EPI 2021 (creatinine), 2012 (cystatin C), or 2021 combined equations as appropriate; body surface area via DuBois & DuBois; and 2- & 5-year kidney failure risk via KFRE (Tangri et al. 2016).

Patient Information
Biomarkers
Anthropometrics — optional; both required for BSA & absolute eGFR

Results

eGFR Estimates
EquationeGFRG-Stage
≤1530456090≥120
UACR Category
Kidney Failure Risk · Tangri 2016 (KFRE)
2-Year Risk
—
5-Year Risk
—

KFRE uses the primary eGFR (cr-cys combined when cystatin C is entered; creatinine-only otherwise).

Equations & Methods:
• eGFRcr CKD-EPI 2021: 142×min(Scr/κ,1)α×max(Scr/κ,1)−1.200×0.9938Age×1.012[F]  (κ=0.7F/0.9M; α=−0.241F/−0.302M)
• eGFRcys CKD-EPI 2012: 133×min(Scys/0.8,1)−0.499×max(Scys/0.8,1)−1.328×0.996Age×0.932[F]
• eGFRcr-cys CKD-EPI 2021: 135×min(Scr/κ,1)α×max(Scr/κ,1)−0.544×min(Scys/0.8,1)−0.323×max(Scys/0.8,1)−0.778×0.9961Age×0.963[F]  (α=−0.219F/−0.144M)
• BSA DuBois 1916: 0.007184×H(cm)0.725×W(kg)0.425  |  Absolute GFR = eGFR×BSA/1.73
• KFRE Tangri 2016: β=−0.2201(age/10−7.036)+0.2467(male−0.5642)−0.5567(eGFR/5−7.222)+0.4510(ln[ACR]−5.137); Risk=1−S₀exp(β); S₀=0.9832(2yr)/0.9365(5yr)

Disclaimer: For use by healthcare professionals only. Not a substitute for clinical judgment. KFRE validated for eGFR 15–59 mL/min/1.73 m².
References
1. Inker LA et al. CKD-EPI 2021 (cr & cr-cys). NEJM 2021;385:1737–1749.
2. Inker LA et al. CKD-EPI cystatin C 2012. NEJM 2012;367:20–29.
3. Tangri N et al. KFRE. JAMA 2016;315:164–174.
4. DuBois D & DuBois EF. Arch Intern Med 1916;17:863–871.
5. KDIGO 2024 CKD Guidelines.  |  6. NIDDK eGFR Equations for Adults.